Abstract | OBJECTIVE: MATERIAL AND METHODS: A total of 80 patients with primary open-angle glaucoma planed for trabeculectomy were randomized into 4 groups of 20 each: 3 groups that differed in the studied drug ( nepafenac, dexamethasone, or their non-fixed combination) and a control group with no preoperative therapy. The patients instilled 1 drop of either drug b.i.d. for 2 weeks before the surgery and were examined each day of the first week and then at weeks 1, 2, 4 and months 3, 6, and 12. The rate of postoperative surgical and medical interventions ( needling, needling revision, hypotensive therapy) was used for outcome evaluation. RESULTS: Postoperative needling was required in 50% of the controls, 35% of the NSAIDs and 30% of the SAIDs patients as well as 20% the combination- therapy patients. Needling revision had to be performed in 10% of patients from the control group and 5% of patients from the NSAIDs group. Patients from the steroid and combination- therapy groups had no need in needling procedure. Further hypotensive therapy was required in 50% of the control group, 35% of the NSAIDs group, 25% of the SAIDs group and 20% of the combination-therapy group. During the first postoperative year complete success of the treatment was achieved in 50% of the controls, 65% of the NSAIDs patients, 75% of the SAIDs patients, and 80% of those under combination therapy. Qualified success during the same period was achieved in 100% of cases. CONCLUSION: Preoperative local anti-inflammatory therapy helped to increase the one-year complete success rate after trabeculectomy as compared with the controls. The most significant hypotensive effect was noted in the combination-therapy group (80%), less significant--in the steroid and non- steroid monotherapy groups (75% and 65% correspondingly). A negative correlation was noted between the use of nepafenac and dexamethasone and other measures aimed at increasing the hypotensive effect of glaucoma surgery.
|
Authors | S Yu Petrov, А А Antonov, А S Makarova, S V Vostrukhin, D М Safonova |
Journal | Vestnik oftalmologii
(Vestn Oftalmol)
2015 Jan-Feb
Vol. 131
Issue 1
Pg. 75-81
ISSN: 0042-465X [Print] Russia (Federation) |
PMID | 25872390
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Antihypertensive Agents
- Benzeneacetamides
- Glucocorticoids
- Ophthalmic Solutions
- Phenylacetates
- nepafenac
- Dexamethasone
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Antihypertensive Agents
(therapeutic use)
- Benzeneacetamides
(administration & dosage)
- Dexamethasone
(administration & dosage)
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Glaucoma, Open-Angle
(drug therapy, physiopathology, surgery)
- Glucocorticoids
(administration & dosage)
- Humans
- Intraocular Pressure
(drug effects)
- Male
- Middle Aged
- Ophthalmic Solutions
- Phenylacetates
(administration & dosage)
- Postoperative Care
(methods)
- Retrospective Studies
- Trabeculectomy
(methods)
|