Abstract | BACKGROUND: The use of thrombolytic agents in the treatment of hemodynamically stable patients with acute submassive pulmonary embolism (PTE) remains controversial. We, therefore, conducted this study to compare the effect of thrombolytic plus anticoagulation versus anticoagulation alone on early death and adverse outcome following submassive PTE. METHODS: RESULTS: Of 50 patients enrolled, 25 patients were randomly assigned to receive an anticoagulant plus a thrombolytic and the other 25 patients were given an anticoagulant alone. The incidence of the primary endpoints was significantly higher in the anticoagulant-alone group than in the thrombolytic-plus- anticoagulant group (p value = 0.022). At the time of discharge, pulmonary artery pressure was significantly higher in the anticoagulant-alone group than in the thrombolytic-plus- anticoagulant group (p value = 0.018); however, reduction in the right ventricular size or normalization of the right ventricle showed non-significant differences between the two groups. There was no significant difference regarding the New York Heat Association (NYHA) functional class between the two groups at the end of the first month (p value = 0.213). No fatal bleeding or cerebral bleeding occurred in the patients receiving an anticoagulant plus a thrombolytic. CONCLUSION:
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Authors | Maryam Taherkhani, Adineh Taherkhani, Seyed Reza Hashemi, Taraneh Faghihi Langroodi, Roxana Sadeghi, Mohammadreza Beyranvand |
Journal | The journal of Tehran Heart Center
(J Tehran Heart Cent)
Vol. 9
Issue 3
Pg. 104-8
( 2014)
ISSN: 1735-5370 [Print] Iran |
PMID | 25870626
(Publication Type: Journal Article)
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