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Antimalarial activity of tulathromycin in a murine model of malaria.

Abstract
There is an urgent need for new antimalarial agents and strategies to treat and control malaria. This study shows an antiplasmodium effect of tulathromycin in mice infected with Plasmodium yoelii. The administration of tulathromycin around the time of infection prevented the progression of disease in 100% of the animals. In addition, highly parasitized mice treated with tulathromycin showed a decreased parasite burden and cleared the parasite faster than did untreated infected mice.
AuthorsNicolas Villarino, Joshua E Denny, Nathan W Schmidt
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 6 Pg. 3672-4 ( 2015) ISSN: 1098-6596 [Electronic] United States
PMID25870067 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015, American Society for Microbiology. All Rights Reserved.
Chemical References
  • Antimalarials
  • Disaccharides
  • Heterocyclic Compounds
  • tulathromycin
Topics
  • Animals
  • Antimalarials (therapeutic use)
  • Disaccharides (therapeutic use)
  • Female
  • Heterocyclic Compounds (therapeutic use)
  • Malaria (drug therapy)
  • Mice
  • Plasmodium yoelii (drug effects, pathogenicity)

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