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Use of infliximab in treatment of acute pancreatitis.

AbstractOBJECTIVE:
The aim of this study was to investigating the effects of infliximab in severe necrotizing pancreatitis.
METHODS:
Forty male Wistar rats were randomly divided into five groups evenly. Necrotizing pancreatitis was induced in group I and II by retrograde injection of 3% taurocholate into common pancreaticobiliary duct. In group III and IV saline was introduced instead of taurocholate to mimic pressure effect. Infliximab (8mg/kg) was infused through tail vein in group I and III and saline was infused in group II and IV just before laparotomy. Group V underwent sham laparotomy. Serum amylase activity, serum and tissue sialic acid, carbonyl content, malondialdehyde, total antioxidant activity (TAA) and pancreatic histopathology were assessed.
RESULTS:
In group I serum sialic acid, malondialdehyde, carbonyl content and amylase activity were significantly lower than in group II (p<0.01). There were no significant differences for serum TAA between group I and II (p>0.05). Tissue sialic acid and malondialdehyde in group I were significantly lower than in group II (p<0.01). But tissue TAA in group I was significantly higher than in group II (p<0.01). Carbonyl content of group I was not significantly different from group II (p>0.05). Histopathologically, pancreatic sections of group II demonstrated extensive acinar and fat necrosis, hemorrhage, and inflammation. In group I Infliximab improved histopathological changes (p0.05).
CONCLUSION:
Administration of infliximab resulted in a significant improvement in biochemical and histopathological alterations in acute necrotizing pancreatitis(Tab. 3, Ref. 43).
AuthorsS Ozcevik Tekin, S Teksoz, D Terzioglu, A E Arikan, H Ozcevik, E Uslu
JournalBratislavske lekarske listy (Bratisl Lek Listy) Vol. 116 Issue 3 Pg. 167-72 ( 2015) ISSN: 0006-9248 [Print] Slovakia
PMID25869565 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibodies, Monoclonal
  • Malondialdehyde
  • Taurocholic Acid
  • Infliximab
  • Amylases
Topics
  • Amylases (metabolism)
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
  • Antibodies, Monoclonal (administration & dosage)
  • Edema (chemically induced, drug therapy)
  • Infliximab
  • Infusions, Intravenous
  • Male
  • Malondialdehyde (metabolism)
  • Pancreas (drug effects, pathology)
  • Pancreatitis, Acute Necrotizing (blood, chemically induced, drug therapy, pathology)
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar
  • Taurocholic Acid

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