Abstract | STUDY DESIGN: OBJECTIVE: The purpose of this study was to provide high-quality evidence regarding the comparative efficacies of TXA, EACA, and placebo in reducing blood loss and transfusion requirements in patients undergoing posterior spinal fusion surgery. SUMMARY OF BACKGROUND DATA: METHODS: Fifty-one patients undergoing posterior spinal fusion of at least 5 levels for correction of adult spinal deformity were randomized to 1 of 3 treatment groups. Primary outcome measures included intraoperative estimated blood loss, total loss, (estimated blood loss + postoperative blood loss), and transfusion rates. RESULTS: Patients received TXA (n = 19), EACA (n = 19), or placebo (n = 13) in the operating room (mean ages: 60, 47, and 43 yr, respectively); TXA patients were significantly older and had larger estimated blood volumes than both other groups. Total losses were significantly reduced for EACA versus control, and there was a demonstrable but nonsignificant trend toward reduced intraoperative blood loss in both antifibrinolytic arms versus control. EACA had significant reductions in postoperative blood transfusions versus TXA. CONCLUSION: LEVEL OF EVIDENCE: 1.
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Authors | Austin Peters, Kushagra Verma, Kseniya Slobodyanyuk, Thomas Cheriyan, Christian Hoelscher, Frank Schwab, Baron Lonner, Tessa Huncke, Virginie Lafage, Thomas Errico |
Journal | Spine
(Spine (Phila Pa 1976))
Vol. 40
Issue 8
Pg. E443-9
(Apr 15 2015)
ISSN: 1528-1159 [Electronic] United States |
PMID | 25868100
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antifibrinolytic Agents
- Tranexamic Acid
- Aminocaproic Acid
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Topics |
- Adult
- Aminocaproic Acid
(therapeutic use)
- Antifibrinolytic Agents
(therapeutic use)
- Blood Loss, Surgical
(prevention & control)
- Blood Transfusion
- Blood Volume
- Double-Blind Method
- Female
- Hematocrit
- Humans
- Intraoperative Care
- Male
- Middle Aged
- Prospective Studies
- Spinal Fusion
- Spine
(abnormalities, surgery)
- Tranexamic Acid
(therapeutic use)
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