Relationship between the concentrations of heavy metals and bioelements in aging men with metabolic syndrome.

Abstract

Heavy metals may exacerbate metabolic syndrome (MS) but abnormal serum concentrations of bioelements may also co-exist with MS. The primary aim of the study was to assess the relationship of blood heavy metal and bioelement concentrations and MS, in men aged 50-75 years. Heavy metals-lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), tungsten (W), Macroelements-magnesium (Mg) and calcium (Ca), and microelements-iron (Fe), zinc (Zn) copper (Cu), chromium (Cr), molybdenum (Mo), selenium (Se) and manganese (Mn), body mass index (BMI), waist to hip ratio (WHR), abdominal circumference (AC) and blood pressure (BP), total cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), fasting plasma glucose (FPG), insulin, and Homeostasis Model Assessment-Insulin resistance (HOMA-IR). The men with MS showed statistically significant higher Zn and lower Mg concentrations. Those with diabetes had higher Ca concentration and lower Mg concentration. Cr and Mn concentrations were significantly higher in obese men. The participants with hypertension had lower Mg concentration. We found statistically significant positive correlations (W-TCh, W-LDL, Mg-TCh, Mg-LDL, Ca-TCh, Ca-LDL, Ca-insulin, Ca-HOMAR-IR, Zn-TG, Zn-insulin, Zn-HOMA-IR, Cu-BP systolic, Mn-BMI, Mn-AC, Mn-WHR, Mn-insulin, Mn-HOMA-IR, Se-TCh, Se-LDL, Se-TG, Se-insulin, Se-HOMA-IR, Cr-TCh, Cr-HDL, Cr-LDL, Cr-TG) and negative correlations (Cd-insulin, Hg-WHR, W-insulin, W-HOMA-IR, Mg-BMI, Mg-AC, Mg-WHR, Mg-BP systolic, Mo-insulin, Mn-HDL). Tungsten may contribute to lipid disorders. Magnesium appears to play the protective role in the occurrence of metabolic disorders. Microelements Mn, Cr and Se may intensify MS.

• Authors: Iwona Rotter, Danuta Kosik-Bogacka, Barbara Dołęgowska, Krzysztof Safranow, Anna Lubkowska, Maria Laszczyńska
• Journal: International journal of environmental research and public health (Int J Environ Res Public Health) Vol. 12 Issue 4 Pg. 3944-61 (Apr 10 2015) ISSN: 1660-4601 [Electronic] Switzerland
• PMID: 25867198 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Metals, Heavy
• Trace Elements

Topics

• Aged
• Environmental Exposure
• Humans
• Male
• Manufacturing Industry
• Metabolic Syndrome (chemically induced, epidemiology)
• Metals, Heavy (toxicity)
• Middle Aged
• Occupational Exposure
• Poland (epidemiology)
• Trace Elements (toxicity)