Abstract | BACKGROUND: OBJECTIVES: In this study, inhibitory effects of four plants including: physalis alkekengi L., Alcea rosea L., Bunium persicum B. Fedtsch. and Marrubium vulgare L. on diphenolase activity of mushroom tyrosinase were evaluated. MATERIALS AND METHODS: The inhibitory activities of hydroalcoholic extracts of plants against oxidation of L-Dopa (as a substrate) by mushroom tyrosinase were investigated. RESULTS: The hydroalcoholic extract of P. alkekengi showed the most tyrosinase inhibitory effect with IC50 of 0.09 mg/mL vs. 0.38, 0.38 and 2.82 mg/mL of B. persicum, A. rosea and M. vulgare, respectively. M. vulgare exhibited uncompetitive inhibition and other plants showed mixed type inhibition on mushroom tyrosinase. CONCLUSIONS: All plants could inhibit mushroom tyrosinase, but more investigations on human tyrosinase and clinical studies are needed.
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Authors | Foroogh Namjoyan, Alireza Jahangiri, Mohammad Ebrahim Azemi, Elaheh Arkian, Hamideh Mousavi |
Journal | Jundishapur journal of natural pharmaceutical products
(Jundishapur J Nat Pharm Prod)
Vol. 10
Issue 1
Pg. e23356
(Feb 2015)
ISSN: 1735-7780 [Print] Netherlands |
PMID | 25866725
(Publication Type: Journal Article)
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