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Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells.

AuthorsVasilis Pericles Androutsopoulos, Irene Fragiadaki, Androniki Tosca
JournalExperimental dermatology (Exp Dermatol) Vol. 24 Issue 8 Pg. 632-4 (Aug 2015) ISSN: 1600-0625 [Electronic] Denmark
PMID25865632 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • 3,4,5,4'-tetramethoxystilbene
  • Antineoplastic Agents
  • Neoplasm Proteins
  • Stilbenes
  • MAPK1 protein, human
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
Topics
  • Antineoplastic Agents (pharmacology)
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Enzyme Activation (drug effects)
  • G2 Phase Cell Cycle Checkpoints (drug effects)
  • Humans
  • MAP Kinase Signaling System (drug effects)
  • Melanoma (pathology)
  • Mitogen-Activated Protein Kinase 1 (physiology)
  • Mitogen-Activated Protein Kinase 3 (physiology)
  • Neoplasm Proteins (physiology)
  • Phosphorylation (drug effects)
  • Protein Processing, Post-Translational (drug effects)
  • Protein Transport (drug effects)
  • Stilbenes (pharmacology)

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