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Recombinant Newcastle disease viral vector expressing hemagglutinin or fusion of canine distemper virus is safe and immunogenic in minks.

Abstract
Canine Distemper Virus (CDV) infects many carnivores and cause several high-mortality disease outbreaks. The current CDV live vaccine cannot be safely used in some exotic species, such as mink and ferret. Here, we generated recombinant lentogenic Newcastle disease virus (NDV) LaSota expressing either envelope glycoproyein, heamagglutinine (H) or fusion protein (F), named as rLa-CDVH and rLa-CDVF, respectively. The feasibility of these recombinant NDVs to serve as live virus-vectored CD vaccine was evaluated in minks. rLa-CDVH induced significant neutralization antibodies (NA) to CDV and provided solid protection against virulent CDV challenge. On the contrast, rLa-CDVF induced much lower NA to CDV and fail to protected mink from virulent CDV challenge. Results suggest that recombinant NDV expressing CDV H is safe and efficient candidate vaccine against CDV in mink, and maybe other host species.
AuthorsJinying Ge, Xijun Wang, Meijie Tian, Yuwei Gao, Zhiyuan Wen, Guimei Yu, Weiwei Zhou, Shulong Zu, Zhigao Bu
JournalVaccine (Vaccine) Vol. 33 Issue 21 Pg. 2457-62 (May 15 2015) ISSN: 1873-2518 [Electronic] Netherlands
PMID25865465 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Drug Carriers
  • Hemagglutinins
  • Vaccines, Attenuated
  • Vaccines, Synthetic
  • Viral Fusion Proteins
  • Viral Vaccines
Topics
  • Animals
  • Antibodies, Neutralizing (blood)
  • Antibodies, Viral (blood)
  • Body Weight
  • Distemper Virus, Canine (genetics, immunology)
  • Drug Carriers
  • Drug-Related Side Effects and Adverse Reactions
  • Genetic Vectors
  • Hemagglutinins (genetics, immunology)
  • Mink
  • Newcastle disease virus (genetics)
  • Survival Analysis
  • Vaccines, Attenuated (administration & dosage, adverse effects, genetics, immunology)
  • Vaccines, Synthetic (administration & dosage, adverse effects, genetics, immunology)
  • Viral Fusion Proteins (genetics, immunology)
  • Viral Vaccines (administration & dosage, adverse effects, genetics, immunology)

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