New cytochalasins from medicinal macrofungus Crodyceps taii and their inhibitory activities against human cancer cells.

Abstract

Three new cytochalasins (1-3) together with two known cytochalasin analogues (4 and 5) were isolated from the chloroform fraction of ethanolic extract of a medicinal macrofungus Cordyceps taii. The structures of the new compounds were elucidated on the basis of spectroscopic analysis, including HRESIMS, 1D and 2D NMR experiments. The cytotoxicities of Compounds 1-5 were investigated by the sulforhodamine B (SRB) method in vitro against human highly metastatic lung cancer cell 95-D, human lung cancer cell line A-549 and normal hepatocyte HL-7702. The results revealed that Compounds 4 and 5 showed potent antitumor activities against human lung cancer cell 95-D with IC50 value of 3.67 and 4.04 μM, respectively. In comparison with cisplatin, the first-line chemotherapy drug, they had little or no cytotoxicity on normal cells, but showed stronger cytotoxic effects on cancer cells 95-D.

• Authors: Xiao-Gang Li, Wei-Dong Pan, Hua-Yong Lou, Ru-Ming Liu, Jian-Hui Xiao, Jian-Jiang Zhong
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 25 Issue 9 Pg. 1823-6 (May 01 2015) ISSN: 1464-3405 [Electronic] England
• PMID: 25863432 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Cytochalasins

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Cell Line
• Cell Proliferation (drug effects)
• Cordyceps (chemistry)
• Cytochalasins (chemistry, isolation & purification, pharmacology)
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• Humans
• Molecular Structure
• Structure-Activity Relationship