Impact of the antipneumococcal conjugate vaccine on the occurrence of infectious respiratory diseases and hospitalization rates in children.

Abstract

INTRODUCTION:

In 2010, to reduce the occurrence of serious pneumococcal disease, the Ministry of Health in Brazil incorporated the 10-valent pneumococcal vaccine in the immunization schedule of children younger than two years of age. The objective of this study was to evaluate the impact of vaccination on the incidence of infectious respiratory diseases in infants before and after the introduction of the 10-valent pneumococcal vaccine.

METHODS:

This cross-sectional study involved primary care and hospital networks from a city in Minas Gerais State, Brazil, between 2009 and 2012.

RESULTS:

A 40% reduction in the prevalence of community-acquired pneumonia (CAP) was observed after introducing the pneumococcal conjugate vaccine. Male children were 28% more likely to develop the disease. The prevalence ratio ([PR] = 1.96, 95% CI: 1.52 to 2.53, p < 0.05) suggested that not being vaccinated was associated with the occurrence of pneumonia. The prevalence of CAP was 70% lower (PR 0.30, 95% CI: 0.24 to 0.37, p<0.05) in children vaccinated as recommended compared to children with delayed vaccination, suggesting that the updated vaccine schedule improves protection.

CONCLUSIONS:

Immunization with the 10-valent pneumococcal vaccine appeared to reduce the number of pneumonia cases in children during the study period. Prospective studies are needed to confirm the efficacy of the vaccine against the occurrence of pneumococcal pneumonia.

• Authors: Wanderci Marys Oliveira Abrão, Luane Marques de Mello, Anderson Soares da Silva, Altacílio Aparecido Nunes
• Journal: Revista da Sociedade Brasileira de Medicina Tropical (Rev Soc Bras Med Trop) 2015 Jan-Feb Vol. 48 Issue 1 Pg. 44-9 ISSN: 1678-9849 [Electronic] Brazil
• PMID: 25860463 (Publication Type: Journal Article)

Chemical References

• 10-valent pneumococcal vaccine
• Pneumococcal Vaccines
• Vaccines, Conjugate

Topics

• Brazil (epidemiology)
• Child, Preschool
• Cross-Sectional Studies
• Female
• Hospitalization (statistics & numerical data)
• Humans
• Infant
• Infant, Newborn
• Male
• Pneumococcal Vaccines (administration & dosage, immunology)
• Pneumonia, Pneumococcal (immunology, prevention & control)
• Prevalence
• Vaccines, Conjugate (administration & dosage, immunology)