Abstract | OBJECTIVE: METHOD: RESULTS: The clozapine/NDMC ratio was significantly and negatively associated with working memory performance after controlling for age, gender, education, and symptom severity. No significant associations were found between individual clozapine and NDMC concentrations and working memory performance. Serum anticholinergic activity was significantly associated with clozapine concentration, but not with working memory performance or NDMC concentration. No significant associations were found between any pharmacological measure and performance on other MCCB cognitive domains. CONCLUSIONS: This hypothesis-driven study confirms that clozapine/NDMC ratio is a strong predictor of working memory performance in patients with schizophrenia. This finding suggests that manipulating the clozapine/NDMC ratio could enhance cognition in patients with schizophrenia treated with clozapine. It also supports the study of procholinergic agents, such as M1 receptor-positive allosteric modulators, to enhance cognition in schizophrenia.
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Authors | Tarek K Rajji, Benoit H Mulsant, Simon Davies, Sawsan M Kalache, Christopher Tsoutsoulas, Bruce G Pollock, Gary Remington |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 172
Issue 6
Pg. 579-85
(Jun 2015)
ISSN: 1535-7228 [Electronic] United States |
PMID | 25859763
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Clozapine
(adverse effects, analogs & derivatives, blood, pharmacokinetics, therapeutic use)
- Female
- Humans
- Male
- Memory, Short-Term
(drug effects)
- Middle Aged
- Neuropsychological Tests
(statistics & numerical data)
- Psychometrics
- Psychotic Disorders
(blood, diagnosis, drug therapy, psychology)
- Schizophrenia
(blood, diagnosis, drug therapy)
- Treatment Outcome
- Young Adult
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