(111)In-octreotide SPECT-CT in head and neck paragangliomas.

Abstract

Head and neck paragangliomas are rare neuroendocrine tumors expressing somatostatin receptors on their cell surface, particularly subtype 2. Due to this distinctive feature, images can be obtained in Nuclear Medicine using synthetic analogues of somatostatin, mainly octreotide, which allow selective display by planar scintigraphy, SPECT-CT or PET-CT imaging after radiolabeling with (111)In or (68)Ga. Three cases have been selected and presented from a series of patients that illustrate the utility of SPECT-CT studies with (111)In-octreotide in the diagnosis and monitoring of this type of tumor. These are characterization at initial diagnosis, staging, and detection of local recurrence or metastasis, with added value with respect to anatomical images (nuclear magnetic resonance, computed axial tomography, angiography), for example in the differentiation between functional tissue or scar in patients who had previously undergone surgery.

• Authors: C Castillo-Berrio, M Castrillón, F Zelaya, D Ruíz, F Loira, J M Nogueiras, A López, R Guitián, J Outomuro, A Serena, L M Campos
• Journal: Revista espanola de medicina nuclear e imagen molecular (Rev Esp Med Nucl Imagen Mol) 2015 Sep-Oct Vol. 34 Issue 5 Pg. 321-4 ISSN: 2253-8070 [Electronic] Spain
• PMID: 25858499 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2014 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

Chemical References

• Indium Radioisotopes
• Radiopharmaceuticals
• Receptors, Somatostatin
• indium-111-octreotide
• Octreotide

Topics

• Carotid Body Tumor (diagnostic imaging, surgery)
• Cicatrix (diagnosis)
• Diagnosis, Differential
• Female
• Glomus Tympanicum Tumor (chemistry, diagnostic imaging, surgery)
• Head and Neck Neoplasms (chemistry, diagnostic imaging, surgery)
• Humans
• Indium Radioisotopes
• Lymphatic Metastasis (diagnostic imaging)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnosis)
• Neoplasm, Residual
• Octreotide (analogs & derivatives)
• Paraganglioma, Extra-Adrenal (chemistry, diagnostic imaging, secondary, surgery)
• Postoperative Complications (diagnosis)
• Radiopharmaceuticals
• Receptors, Somatostatin (analysis)
• Single Photon Emission Computed Tomography Computed Tomography