Metallothionein immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour.

Abstract

BACKGROUND:

To compare the metallothionein (MT) immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour (KOT), to correlate MT with cellular proliferation, and to evaluate the influence of inflammation in MT.

STUDY DESIGN:

Fourteen cases of KOT were submitted to immunohistochemistry for MT and Ki-67 analysis. The lesions were grouped according to their grade of inflammation, and statistical analysis was performed.

RESULTS:

MT was higher in non-syndromic KOT than in syndromic KOT (p<0.05). No statistical difference in Ki-67 could be identified; however, an inverse correlation was observed between MT and Ki-67 in both lesions. When analysing inflammation, non-syndromic KOT showed no differences in either MT or Ki-67.

CONCLUSIONS:

The MT immunophenotype of syndromic KOT was different from non-syndromic KOT. MT might not be involved in the proliferation control of both KOT. MT and Ki-67 immunoexpressions proved to be unaffected by inflammation in non-syndromic KOT.

• Authors: Aline-Cristina-Batista-Rodrigues Johann, Patrícia-Carlos Caldeira, Marcelo-Vidigal Caliari, Ricardo-Santiago Gomez, Maria-Cássia-Ferreira Aguiar, Ricardo-Alves Mesquita
• Journal: Medicina oral, patologia oral y cirugia bucal (Med Oral Patol Oral Cir Bucal) Vol. 20 Issue 4 Pg. e408-12 (Jul 01 2015) ISSN: 1698-6946 [Electronic] Spain
• PMID: 25858080 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ki-67 Antigen
• Metallothionein

Topics

• Humans
• Immunohistochemistry
• Ki-67 Antigen (biosynthesis, immunology)
• Metallothionein (biosynthesis, immunology)
• Odontogenic Cysts (immunology, metabolism, pathology)
• Syndrome