Abstract | CONTEXT: OBJECTIVE: MATERIALS AND METHODS: Mice were randomized into five groups: Group I mice served as control. Group II mice received 5 × MPTP [25 mg/kg body weight (i.p.)] in saline 24 h apart starting from the 3rd day and continued till the last day of the experimental period of 7 d. In addition to MPTP injections, mice in Groups III, IV, and V were given FA at a dose of 20, 40, and 80 mg, respectively, for 7 d. Mice were subjected to a battery of behavioral tests along with histological investigations. RESULTS: Our histological findings revealed that MPTP administration enhanced Bax/Bcl2 ratio and microglial cells activation reflecting induction of apoptosis and inflammation, respectively. This dopaminergic neuronal loss caused impairment in motor balance and coordination in MPTP mice as assessed by various behavioral tests. FA at a dose of 40 mg/kg/d body weight effectively attenuated MPTP-induced neurotoxicity. DISCUSSION: CONCLUSION: This study provides elementary evidence for the neuroprotective action of FA against MPTP-induced PD in mice and warrants further studies.
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Authors | Sangeetha Nagarajan, David Raj Chellappan, Prabu Chinnaswamy, Senthilkumar Thulasingam |
Journal | Pharmaceutical biology
(Pharm Biol)
Vol. 53
Issue 11
Pg. 1591-601
( 2015)
ISSN: 1744-5116 [Electronic] England |
PMID | 25857436
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Coumaric Acids
- Neuroprotective Agents
- ferulic acid
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Topics |
- Animals
- Cell Death
(drug effects)
- Coumaric Acids
(administration & dosage)
- MPTP Poisoning
(chemically induced, pathology, prevention & control)
- Male
- Mice
- Mice, Inbred C57BL
- Motor Skills Disorders
(chemically induced, pathology, prevention & control)
- Neuroprotective Agents
(administration & dosage)
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