Abstract | BACKGROUND: HYPOTHESIS/OBJECTIVES: It was hypothesized that racehorses with inflammatory airway disease (IAD) have increased concentration of circulating acute phase proteins. The objective of this study was to compare serum acute phase proteins of racehorses with and without lower airway inflammation. ANIMALS: Serum from 21 client-owned Standardbred racehorses with exercise intolerance and lower airway inflammation and serum from 10 client-owned Standardbred racehorses with exercise intolerance without lower airway inflammation. METHODS: RESULTS: There was no significant differences between groups for SAA (non-IAD versus IAD, median (range): 3.47 (0.06-34.94) versus 6.33 (0.06-80) μg/mL, P = .49), CRP (10.87 (2.05-29.03) versus 4.63 (0.02-31.81) μg/mL, P = .23) or haptoglobin (900.36 (607.99-2018.84) versus 749.54 (530.81-1076.95) μg/mL, P = .09). CONCLUSIONS AND CLINICAL IMPORTANCE: In this population of poorly performing racehorses in training, serum SAA, CRP, and haptoglobin were not helpful in distinguishing between horses with IAD from horses with exercise intolerance from other causes.
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Authors | M Leclere, A Lavoie-Lamoureux, J-P Lavoie |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2015 May-Jun
Vol. 29
Issue 3
Pg. 940-5
ISSN: 1939-1676 [Electronic] United States |
PMID | 25857218
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. |
Chemical References |
- Acute-Phase Proteins
- Haptoglobins
- Serum Amyloid A Protein
- C-Reactive Protein
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Topics |
- Acute-Phase Proteins
(analysis)
- Animals
- Bronchoalveolar Lavage Fluid
(cytology)
- C-Reactive Protein
(analysis)
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
(veterinary)
- Female
- Haptoglobins
(analysis)
- Horse Diseases
(blood)
- Horses
- Inflammation
(blood, veterinary)
- Male
- Respiratory Tract Diseases
(blood, veterinary)
- Serum Amyloid A Protein
(analysis)
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