Study on the effect of urinary kallidinogenase after thrombolytic treatment for acute cerebral infarction.

Abstract

OBJECTIVE:

To evaluate the safety and efficacy of urinary kallidinogenase for recombinant tissue-type plasminogen activator (rt-PA) intravenous thrombolytic treatment in patients with acute cerebral infarction.

PATIENTS AND METHODS:

All 200 patients with acute cerebral infarction were randomized 1:1 into an experimental group (100 cases) and a control group (100 cases). Patients in the control group were administrated rt-PA (0/9 mg/kg) while patients in the experimental group were given urinary kallidinogenase by intravenous drip (0.15 PNAU/d, for 7 days) after rt-PA intravenous thrombolytic treatment (0.9 mg/kg). The main evaluation index was NIHSS and BI.

RESULTS:

Compared to the control group, the NIHSS scores were significantly lower 7 and 90 days after thrombolytic therapy (t = 2.391, 2.714; p < 0.05). BI scores were obviously higher at 90 days after thrombolytic therapy in the experimental group (t = 2.675, p < 0.05).

CONCLUSIONS:

Urinary kallidinogenase may improve the treatment effect for rt-PA intravenous thrombolytic treatment in patients with acute cerebral infraction.

• Authors: Y-X Wang, Y Chen, C-H Zhang, C-H Li, Z Dong, S-N Zhao, Z Wang, F-F Zhang, X-G Tong, J-H Wang, P-L Zhang
• Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 19 Issue 6 Pg. 1009-12 ( 2015) ISSN: 2284-0729 [Electronic] Italy
• PMID: 25855926 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Fibrinolytic Agents
• Kallikreins
• Tissue Plasminogen Activator

Topics

• Acute Disease
• Adult
• Aged
• Aged, 80 and over
• Cerebral Infarction (drug therapy, etiology, urine)
• Female
• Fibrinolytic Agents (therapeutic use)
• Humans
• Kallikreins (administration & dosage, urine)
• Male
• Middle Aged
• Thrombolytic Therapy (trends)
• Tissue Plasminogen Activator (administration & dosage)
• Treatment Outcome