Diagnosis value of membrane glycolipids biochemistry index in intracranial and gastrointestinal tumors.

Abstract

The diagnostic value of membrane glycolipid biochemistry index, the lipid-bound sialic acid (LSA) and total sialic acid (TSA) in cerebrospinal fluid (CSF) was evaluated in 30 intracranial and 65 gastrointestinal tumors. The plasma LSA, TSA and red cell membrane sialic acid (R-SA) in were determined according to the method of Sevenmerhulm. Our results showed that the levels of LSA and TSA in CSF of intracranial tumor patients was higher than that of normal group(p<0.01). The concentration of TSA and LSA in patients with malignant glioma was higher than that of benign meningioma patients(P<0.01). No significance was found between intracranial halmatoma patients and normal control group for levels of membrane glycolipids (p>0.05). Results also found that the plasma LSA, TSA and R-SA of gastric carcinoma were significantly higher than those of control group (p<0.05); while no significant difference was found in the plasma LSA, TSA and R-SA levels between chronic gastritis, gastrohelcoma and normal control group (p>0.05). Plasma LSA, TSA and R-SA levels of gastric carcinoma patient were significantly higher than those of chronic gastritis patients and gastrohelcoma patients(p<0.05). It was also found that plasma LSA, TSA and R-SA contents were significantly higher in large intestine carcinoma patients than in benign in stestine tumor patients (p<0.05) while no significant difference was found between intestine benign tumor and normal control group (p>0.05). The levels of LSA, TSA and R-SA were obviously higher in the patients with metastasis than in the ones without (p<0.05.) The membrane glycolipid biochemistry index LSA and TSA in CSF are sensive markers for diagnosing intracranial tumors. For gastrointestinal malignant tumors the plasma LSA TSA and red blood cell membrane SA may be considered as auxiliary indicators for diagnosis. They can be used for distinguishing benign from malignant tumors.

• Authors: Jun Lv, Can-Qun Lv, Ping Mei, Shi-Mei Qi
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 16 Issue 7 Pg. 2693-6 ( 2015) ISSN: 2476-762X [Electronic] Thailand
• PMID: 25854348 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Gangliosides
• Glycolipids
• N-Acetylneuraminic Acid

Topics

• Biomarkers, Tumor (blood, cerebrospinal fluid, metabolism)
• Brain Neoplasms (diagnosis, pathology)
• Erythrocyte Membrane (metabolism)
• Gangliosides (blood, cerebrospinal fluid, metabolism)
• Gastritis (pathology)
• Gastrointestinal Neoplasms (diagnosis, pathology)
• Glioma (diagnosis, pathology)
• Glycolipids (blood, cerebrospinal fluid, metabolism)
• Humans
• Meningioma (diagnosis, pathology)
• N-Acetylneuraminic Acid (blood, cerebrospinal fluid, metabolism)