Prognostic significance of autocrine motility factor receptor expression by colorectal cancer and lymph node metastases.

Abstract

BACKGROUND:

Autocrine motility factor receptor (AMFR) has been linked to metastasis and tumorigenicity. The aim of this study was to evaluate expression and prognostic significance of AMFR in colorectal carcinoma.

METHODS:

AMFR expression was evaluated in 127 colon cancer specimens, 131 rectal cancer specimens, and 47 colonic and 25 rectal corresponding lymph node metastases. Clinicopathological correlates of prognostic significance were established by univariate and multivariate analysis. Spearman's correlation determined the association of expression between cancers and their metastases.

RESULTS:

AMFR was over-expressed by 22% of colon cancers and 18% of rectal cancers. AMFR over-expression correlated significantly with improved disease-free survival (DFS) (P < .05) in colon cancer and decreased DFS in corresponding nodal metastases. In rectal cancer, AMFR over-expression significantly correlated with decreased overall survival, DFS, and disease-specific survival (P < .001, P = .031, P = .005, respectively) and decreased overall survival in corresponding metastases.

CONCLUSION:

AMFR may serve as a molecular prognosticator for colon cancer and rectal cancer.

• Authors: Yasmin Halwani, Liliana D Kojic, Simon K Chan, Terry P Phang, Hamid Masoudi, Steven J M Jones, Ivan R Nabi, Sam M Wiseman
• Journal: American journal of surgery (Am J Surg) Vol. 209 Issue 5 Pg. 884-9; discussion 889 (May 2015) ISSN: 1879-1883 [Electronic] United States
• PMID: 25852009 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• AMFR protein, human
• Receptors, Autocrine Motility Factor

Topics

• Biomarkers, Tumor (biosynthesis)
• Blotting, Western
• Cell Line, Tumor
• Colorectal Neoplasms (diagnosis, metabolism, secondary)
• Flow Cytometry
• Humans
• Immunohistochemistry
• Lymph Nodes (metabolism, pathology)
• Lymphatic Metastasis
• Neoplasm Staging
• Prognosis
• Receptors, Autocrine Motility Factor (biosynthesis)
• Retrospective Studies