Abstract | BACKGROUND:
Butyrophilin-like 2 (BTNL2) rs2076530 gene polymorphism has been implicated in susceptibility to sarcoidosis. However, results from previous studies are not consistent. To assess the association of BTNL2 polymorphism and sarcoidosis susceptibility, a meta-analysis was performed. METHODS: PubMed, Embase were searched for eligible case-control studies. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. RESULTS: Ten studies involving a total of 3303 cases and 2514 controls were included in this meta-analysis. Combined data indicated that BTNL2 rs2076530 polymorphism was associated with sarcoidosis susceptibility in allelic model (A vs. G, OR = 1.59, 95%CI: 1.47-1.72), dominant model (AA + AG vs. GG, OR = 2.10, 95%CI: 1.67-2.65), and recessive model (AA vs. AG + GG, OR = 1.93, 95%CI: 1.49-2.50). CONCLUSIONS: This meta-analysis indicates that BTNL2 rs2076530 polymorphism contributes to the risk of sarcoidosis.
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Authors | Yihua Lin, Jia Wei, Lili Fan, Deyun Cheng |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 4
Pg. e0122639
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25849037
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- BTNL2 protein, human
- Butyrophilins
- Membrane Glycoproteins
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Topics |
- Butyrophilins
- Genetic Predisposition to Disease
(genetics)
- Humans
- Membrane Glycoproteins
(genetics)
- Polymorphism, Single Nucleotide
- Sarcoidosis
(genetics)
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