Asphyxia-activated corticocardiac signaling accelerates onset of cardiac arrest.
|
| Abstract |
The mechanism by which the healthy heart and brain die rapidly in the absence of oxygen is not well understood. We performed continuous electrocardiography and electroencephalography in rats undergoing experimental asphyxia and analyzed cortical release of core neurotransmitters, changes in brain and heart electrical activity, and brain-heart connectivity. Asphyxia stimulates a robust and sustained increase of functional and effective cortical connectivity, an immediate increase in cortical release of a large set of neurotransmitters, and a delayed activation of corticocardiac functional and effective connectivity that persists until the onset of ventricular fibrillation. Blocking the brain's autonomic outflow significantly delayed terminal ventricular fibrillation and lengthened the duration of detectable cortical activities despite the continued absence of oxygen. These results demonstrate that asphyxia activates a brainstorm, which accelerates premature death of the heart and the brain.
|
|---|---|
| Authors | Duan Li, Omar S Mabrouk, Tiecheng Liu, Fangyun Tian, Gang Xu, Santiago Rengifo, Sarah J Choi, Abhay Mathur, Charles P Crooks, Robert T Kennedy, Michael M Wang, Hamid Ghanbari, Jimo Borjigin |
| Journal | Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 112 Issue 16 Pg. E2073-82 (Apr 21 2015) ISSN: 1091-6490 [Electronic] United States |
| PMID | 25848007 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!