Angiotensins as therapeutic targets beyond heart disease.

Abstract

The renin-angiotensin system (RAS) plays a pivotal role in cardiovascular and hydro-electrolyte homeostasis. Blockade of the RAS as a therapeutic strategy for treating hypertension and related cardiovascular diseases is well established. However, actions of the RAS go far beyond the targets initially described. In this regard, the recent identification of novel components of the RAS, including angiotensin-(1-7) [Ang-(1-7)], Ang-(1-9), and alamandine, have opened new possibilities for interfering with the development and manifestations of cardiovascular and non-cardiovascular diseases. In this article, we briefly review novel targets for angiotensins and its therapeutic implications in diverse areas, including cancer, inflammation, and glaucoma.

• Authors: Danielle Gomes Passos-Silva, Enrique Brandan, Robson Augusto Souza Santos
• Journal: Trends in pharmacological sciences (Trends Pharmacol Sci) Vol. 36 Issue 5 Pg. 310-20 (May 2015) ISSN: 1873-3735 [Electronic] England
• PMID: 25847571 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Angiotensin-Converting Enzyme Inhibitors

Topics

• Angiotensin-Converting Enzyme Inhibitors (pharmacology, therapeutic use)
• Animals
• Erectile Dysfunction (drug therapy, metabolism)
• Glaucoma (drug therapy, metabolism)
• Heart Diseases (drug therapy, metabolism)
• Humans
• Liver Cirrhosis (drug therapy, metabolism)
• Male
• Pulmonary Fibrosis (drug therapy, metabolism)
• Renin-Angiotensin System