Abstract | UNLABELLED: CONCLUSION: The CaMKK2/CaMKIV relay is an upstream regulator of the oncogenic mammalian target of rapamycin/ ribosomal protein S6 kinase, 70 kDa, pathway, and the importance of this CaMKK2/CaMKIV axis in HCC growth is confirmed by the potent growth inhibitory effects of genetically or pharmacologically decreasing CaMKK2 activity; collectively, these findings suggest that CaMKK2 and CaMKIV may represent potential targets for hepatic cancer.
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Authors | Fumin Lin, Kathrina L Marcelo, Kimal Rajapakshe, Cristian Coarfa, Adam Dean, Nathaniel Wilganowski, Holly Robinson, Eva Sevick, Karl-Dimiter Bissig, Lauren C Goldie, Anthony R Means, Brian York |
Journal | Hepatology (Baltimore, Md.)
(Hepatology)
Vol. 62
Issue 2
Pg. 505-20
(Aug 2015)
ISSN: 1527-3350 [Electronic] United States |
PMID | 25847065
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 by the American Association for the Study of Liver Diseases. |
Chemical References |
- CAMKK2 protein, human
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
- Calcium-Calmodulin-Dependent Protein Kinase Type 4
- Camk4 protein, mouse
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Topics |
- Animals
- Biopsy, Needle
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
(genetics)
- Calcium-Calmodulin-Dependent Protein Kinase Type 4
(genetics)
- Carcinoma, Hepatocellular
(diagnostic imaging, genetics, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Liver Neoplasms
(diagnostic imaging, genetics, pathology)
- Male
- Mice
- Mice, Inbred Strains
- Positron-Emission Tomography
- Survival Rate
- Tumor Cells, Cultured
- Up-Regulation
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