[Mechanisms of the antitumor action of spirobromine in mice with leukemia P-388].

Abstract

The influence of new antitumor drug, spirobromine, a derivative of dispirotripiperazine, on DNA synthesis in tumor cells and organs at different times after its injection into mice with P388 leukemia has been studied. The duration of DNA synthesis inhibition in tumor cells was found to correlate with spirobromine antitumor activity. A certain selectivity of action of the studied compound on DNA synthesis in P 388 leukemia cells as compared to the action on DNA synthesis in bone marrow, small intestine, spleen and liver of tumor animals was observed.

• Authors: I S Sokolova, N A Riabokon', V A Chernov, L B Gorbacheva
• Journal: Izvestiia Akademii nauk SSSR. Seriia biologicheskaia (Izv Akad Nauk SSSR Biol) 1989 Sep-Oct Issue 5 Pg. 660-5 ISSN: 0002-3329 [Print] Russia (Federation)
• Vernacular Title: Izuchgenie mekhanizma protivoopukholevogo deĭstviia spirobromina u mysheĭ s leĭkozom P-388.
• PMID: 2584530 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• DNA, Neoplasm
• Spiro Compounds
• spirobromin

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• DNA, Neoplasm (biosynthesis, drug effects)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Leukemia P388 (drug therapy, metabolism)
• Leukemia, Experimental
• Mice
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Neoplasm Transplantation
• Spiro Compounds (therapeutic use)
• Time Factors