Abstract |
Anaphylaxis results from severe systemic mast cell activation. In addition to IgE-mediated and physical triggers, it may occur with a clonal mast cell disease and in an idiopathic fashion without clear provoking factors. Disorders of mast cell activation are classified into primary (clonal), secondary, and idiopathic. Mast cell activation syndrome (MCAS) is a multisystem disorder characterized by objective documentation of elevated mast cell mediators during attacks and a favorable response to antimediator therapy. It should be considered in the differential diagnosis of patients presenting with recurrent anaphylaxis without a clear cause. This article discusses the diagnosis of MCAS.
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Authors | Cem Akin |
Journal | Immunology and allergy clinics of North America
(Immunol Allergy Clin North Am)
Vol. 35
Issue 2
Pg. 277-85
(May 2015)
ISSN: 1557-8607 [Electronic] United States |
PMID | 25841551
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Anaphylaxis
(diagnosis, immunology, therapy)
- Clonal Evolution
(immunology)
- Diagnosis, Differential
- Disease Management
- Humans
- Immunoglobulin E
(immunology)
- Mast Cells
(immunology)
- Mastocytosis
(diagnosis, immunology, therapy)
- Syndrome
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