Abstract |
We evaluated the prognostic significance of a modified European LeukemiaNet (ELN) classification for patients with acute myelogenous leukemia (AML) undergoing hematopoietic stem cell transplantation (HSCT) while in first complete remission (CR1). We analyzed 464 AML patients with matched related (n = 211, 45.5%), matched unrelated (n = 176, 37.9%), and mismatched donors (n = 77, 16.6%). Patients were classified into 4 modified ELN risk groups (favorable, intermediate-I, intermediate-II, and adverse) separately for 354 patients age < 60 years and 110 patients age ≥ 60 years. In this modified version of ELN classification, patients with normal cytogenetic were classified by FLT3-ITD mutational status: favorable risk if FLT3-ITDwild and intermediate-I if FLT3-ITDmut. The best outcomes occurred in the ELN favorable and intermediate-II groups in younger AML patients and in the favorable and intermediate-I groups in older AML patients. Older AML patients had worse transplant outcomes within each modified ELN risk group except intermediate-I when compared with younger patients; leukemia-free survival at 3 years was 67.8% versus 49.8% in favorable, 53.4% versus 50.7% in intermediate-I, 65.7% versus 20.2% in intermediate-II, and 44.6% versus 23.8% in adverse group younger and older patients, respectively. Among lesion-specific abnormalities, del5q/-5 and abnl(17p) had the worse transplant outcomes, with 3-year leukemia-free survival rates of 18.4% and 20% in younger CR1 patients. In conclusion, the modified ELN prognostic classification developed for chemotherapy outcomes also identifies prognostic groups for HSCT, which is useful for a selection of patients for post-transplant strategies to improve outcomes.
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Authors | Betül Oran, Antonio M Jimenez, Marcos De Lima, Uday R Popat, Roland Bassett, Borje Andersson, Gautam Borthakur, Qaiser Bashir, Julianne Chen, Stefan O Ciurea, Elias Jabbour, Jorge Cortes, Partow Kebriaei, Issa F Khouri, Muzaffar H Qazilbash, Farhad Ravandi, Gabriela Rondon, Xinyan Lu, Elizabeth J Shpall, Richard E Champlin |
Journal | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
(Biol Blood Marrow Transplant)
Vol. 21
Issue 8
Pg. 1405-1412
(Aug 2015)
ISSN: 1523-6536 [Electronic] United States |
PMID | 25840338
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Age Factors
- Europe
- Female
- Hematopoietic Stem Cell Transplantation
(methods)
- Humans
- Leukemia, Myeloid, Acute
(classification, genetics, surgery)
- Male
- Middle Aged
- Retrospective Studies
- Risk Factors
- Survival Rate
- Transplantation Conditioning
(methods)
- Transplantation, Homologous
- Treatment Outcome
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