Abstract | BACKGROUND/PURPOSE: METHODS: RESULTS: Treatment with 2 μM SPC inhibited the increase in lung MDA and NO levels significantly and also attenuated the depletion of SOD, GPx, and GSH in the lung injury induced by pulmonary contusion. These data were supported by histopathological findings. The inducible nitric oxide synthase (iNOS) positive cells and apoptotic cells in the lung tissue were observed to be reduced with the 2 μM SPC treatment. But, the 10 μM SPC treatment did not provide similar effects. CONCLUSIONS: In conclusion, these findings suggested that 2 μM SPC can attenuate lung damage in pulmonary contusion by prevention of oxidative stress, inflammatory process and apoptosis. All these findings suggest that low dose SPC may be a promising new therapeutic agent for acute lung injury.
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Authors | Burhan Aksu, Süleyman Ayvaz, Feyza Aksu, Turan Karaca, Mustafa Cemek, Ahmet Ayaz, Selim Demirtaş |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 50
Issue 4
Pg. 591-7
(Apr 2015)
ISSN: 1531-5037 [Electronic] United States |
PMID | 25840069
(Publication Type: Evaluation Study, Journal Article)
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Copyright | Copyright © 2015. Published by Elsevier Inc. |
Chemical References |
- Protective Agents
- sphingosine phosphorylcholine
- Phosphorylcholine
- Sphingosine
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Topics |
- Acute Lung Injury
(etiology, prevention & control)
- Animals
- Contusions
(complications)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Injections, Intraperitoneal
- Oxidative Stress
(drug effects)
- Phosphorylcholine
(analogs & derivatives, pharmacology, therapeutic use)
- Protective Agents
(pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Sphingosine
(analogs & derivatives, pharmacology, therapeutic use)
- Treatment Outcome
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