Evaluation of edaravone against radiation-induced oral mucositis in mice.

Abstract

Oral mucositis induced by radiotherapy for cancers of the head and neck reduce the quality of life of patients. However, effective therapeutic agents are lacking. Symptomatic treatment involves local anesthesia and analgesia. We focused on the antioxidant effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one; Radicut(®)). Oral mucositis was induced on the tongue tips of mice using a single dose of X-rays (20 Gy). To evaluate the protective effect of edaravone (30 and 300 mg/kg), administration was carried out 30 min before irradiation. Survival, oral mucositis score, myeloperoxidase activity, and levels of 2-Thiobarbituric acid reactive substances were measured, and all were improved compared with those of control mice. A significant difference was not found in terms of survival due to edaravone. Histopathologic findings also highlighted the beneficial features of edaravone. Edaravone reduced the production of reactive oxygen species. These findings suggest that the protective effect of edaravone against radiation-induced oral mucositis is through an antioxidant effect.

• Authors: Noriko Nakajima, Shinichi Watanabe, Takeshi Kiyoi, Akihiro Tanaka, Katsuya Suemaru, Hiroaki Araki
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 127 Issue 3 Pg. 339-43 (Mar 2015) ISSN: 1347-8648 [Electronic] Japan
• PMID: 25837932 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. All rights reserved.

Chemical References

• Antioxidants
• Reactive Oxygen Species
• Thiobarbiturates
• Peroxidase
• thiobarbituric acid
• Edaravone
• Antipyrine

Topics

• Animals
• Antioxidants
• Antipyrine (analogs & derivatives, pharmacology, therapeutic use)
• Edaravone
• Mice, Inbred ICR
• Peroxidase (metabolism)
• Radiation Dosage
• Radiation Injuries, Experimental (etiology, metabolism, prevention & control)
• Reactive Oxygen Species (metabolism)
• Stomatitis (etiology, metabolism, prevention & control)
• Thiobarbiturates (metabolism)