Benign brain tumors and tumors associated with phakomatoses.

Abstract

PURPOSE OF REVIEW:

This article reviews the clinical features, diagnostic criteria, molecular genetics, and management of sporadic meningiomas and vestibular schwannomas and tumors associated with the major neurocutaneous disorders.

RECENT FINDINGS:

Recent advances in cancer genomics are now allowing sequencing of the genome of these tumors to identify oncogenic drivers and possible therapeutic targets.

SUMMARY:

Sporadic meningiomas and schwannomas, and tumors occurring as part of a neurocutaneous syndrome, have been the subjects of strong biological and therapeutic interest in the past few years; new and exciting therapies are either under investigation or will be in the upcoming years. This article takes an in-depth look at sporadic meningiomas and schwannomas, followed by a review of the phakomatoses and their associated tumors.

• Authors: Mariza Daras, Thomas J Kaley
• Journal: Continuum (Minneapolis, Minn.) (Continuum (Minneap Minn)) Vol. 21 Issue 2 Neuro-oncology Pg. 397-414 (Apr 2015) ISSN: 1538-6899 [Electronic] United States
• PMID: 25837903 (Publication Type: Journal Article, Review)

Topics

• Brain Neoplasms (diagnosis, genetics, therapy)
• Genome
• Genomics
• Humans
• Meningioma (genetics, therapy)
• Neurocutaneous Syndromes (diagnosis, genetics, physiopathology, therapy)
• Neuroma, Acoustic (genetics, therapy)