Acute hyperkinetic syndrome due to ephedrone abuse.

Abstract

OBJECTIVES:

A new form of manganese poisoning is related to the intravenous use of self-prepared methcathinone hydrochloride (ephedrone). Manganese encephalopathy typically manifests as a levodopa-resistant parkinsonism.

MAIN POINTS:

A 32-year-old drug-addicted man with acute gait disturbances after the ephedrone injections was presented. Choreic movements, severe postural instability, and "cock-walk" gait were observed. Magnetic resonance imaging T1 images showed high signal intensity of white matter in the basal ganglia and pituitary gland, and T2 images showed decreased signal mostly of globus pallidus with decreased N-acetylaspartate and choline levels in MR spectroscopy.

CONCLUSIONS:

The unusual pattern of MR imaging may explain the unusual clinical symptoms with dominant hyperkinetic syndrome.

• Authors: Anna Dolgan, Slawomir Budrewicz, Magdalena Koszewicz, Joanna Bladowska, Krzysztof Slotwinski, Mieszko Zagrajek, Ewa Koziorowska-Gawron, Ryszard Podemski
• Journal: Journal of addiction medicine (J Addict Med) 2015 May-Jun Vol. 9 Issue 3 Pg. 244-5 ISSN: 1935-3227 [Electronic] United States
• PMID: 25835774 (Publication Type: Case Reports, Journal Article)

Chemical References

• Propiophenones
• monomethylpropion

Topics

• Acute Disease
• Adult
• Brain (pathology)
• Humans
• Hyperkinesis (chemically induced, pathology)
• Magnetic Resonance Imaging
• Male
• Neuroimaging
• Propiophenones (adverse effects)
• Substance-Related Disorders (complications, pathology)