Solifenacin/tamsulosin fixed-dose combination therapy to treat lower urinary tract symptoms in patients with benign prostatic hyperplasia.

Abstract

Treatment of male lower urinary tract symptoms (LUTS) has traditionally focused on the management of benign prostatic obstruction, but the contribution of bladder dysfunction has been recently recognized. Therefore, it is well understood that LUTS have multifactorial etiology and often occur in clusters and not in isolation. Voiding LUTS are highly prevalent in men, but storage LUTS have been proved to be more bothersome. α1-Blockers are the most widely used pharmacologic agents for the treatment of symptoms relating to benign prostatic enlargement due to benign prostatic hyperplasia (BPH), while antimuscarinics are the drug class of choice for overactive bladder symptoms. A combination of the two drug classes would be a reasonable approach to treat men with both storage and voiding symptoms, and several short-term studies have proved the efficacy and safety of different combinations with an α1-blocker and an antimuscarinic. Following previous studies on the separate administration of solifenacin and tamsulosin, a fixed-dose combination tablet of tamsulosin oral controlled absorption system (OCAS) 0.4 mg and solifenacin succinate 6 mg has been recently introduced, and the current review evaluates the available data on the use of this fixed-dose combination in the treatment of LUTS in men with BPH.

• Authors: Konstantinos Dimitropoulos, Stavros Gravas
• Journal: Drug design, development and therapy (Drug Des Devel Ther) Vol. 9 Pg. 1707-16 ( 2015) ISSN: 1177-8881 [Electronic] New Zealand
• PMID: 25834406 (Publication Type: Journal Article, Review)

Chemical References

• Sulfonamides
• Tamsulosin
• Solifenacin Succinate

Topics

• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Humans
• Lower Urinary Tract Symptoms (complications, drug therapy)
• Male
• Prostatic Hyperplasia (complications, drug therapy)
• Solifenacin Succinate (administration & dosage, therapeutic use)
• Sulfonamides (administration & dosage, therapeutic use)
• Tamsulosin