Abstract | OBJECTIVE: METHODS: VIRTUE was a multicenter, prospective, observational study, which enrolled 244 patients from Pakistan who were re-analysed. All included patients were treated with vildagliptin (n=121) or SU (n=121) as add-on to metformin or as monotherapy for 16 weeks. The primary outcome of interest was to compare the proportion of patients with ≥1 hypoglycaemic event (HE) during fasting between vildagliptin and SU cohort. Changes in HbA1c and body weight and treatment adherence were also measured. RESULTS: Of the 244 patients enrolled, 120 patients in the vildagliptin cohort (99.2%) and 119 patients in the SU cohort (98.3%) completed the study. Patients experiencing at least one HE were fewer with vildagliptin when compared with SUs (5.8% vs. 14.2%; p<0.033). The reduction in HbA1c was 0.3% with vildagliptin from a baseline of 7.6% and 0.1% with SU from a baseline of 7.4% (between-treatment difference: -0.1% p<0.054). A reduction of 0.3 kg was seen with vildagliptin treatment vs. 0.2 kg weight gain in the SU group. Adverse events were experienced by 15.7% in the vildagliptin cohort and 17.4% in the SU group. CONCLUSION: The treatment with vildagliptin was associated with fewer hypoglycaemic events compared with SUs and was well tolerated with good glycaemic and weight control in patients with T2DM fasting during Ramadan.
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Authors | Saeed Ahmed Mahar, Mohammad Imtiaz Hasan, Mohammad Imran Hasan Khan, Asher Fawwad, Shakir Hussain, Neeta Maheshwary, Kishore Kumar, Ahson Siddiqi, Muhammad Athar Khan |
Journal | JPMA. The Journal of the Pakistan Medical Association
(J Pak Med Assoc)
Vol. 64
Issue 11
Pg. 1297-302
(Nov 2014)
ISSN: 0030-9982 [Print] Pakistan |
PMID | 25831650
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypoglycemic Agents
- Nitriles
- Pyrrolidines
- Sulfonylurea Compounds
- Vildagliptin
- Adamantane
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Topics |
- Adamantane
(analogs & derivatives, therapeutic use)
- Adult
- Aged
- Cohort Studies
- Diabetes Mellitus, Type 2
(complications, drug therapy, ethnology)
- Fasting
- Female
- Humans
- Hypoglycemia
(epidemiology)
- Hypoglycemic Agents
(therapeutic use)
- Islam
- Male
- Middle Aged
- Nitriles
(therapeutic use)
- Pakistan
- Pyrrolidines
(therapeutic use)
- Sulfonylurea Compounds
(therapeutic use)
- Vildagliptin
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