Abstract | OBJECTIVES: DESIGN AND METHODS: We measured plasma concentrations of arginine (P- arginine), ADMA (P-ADMA), SDMA (P-SDMA), homoarginine (P- homoarginine) and other covariates in 160 patients with predialytic CKD (mean age 57 years and mean eGFR 43 mL/min/1.73 m(2)) and followed them for 58 months in median. The risks of fatal and non-fatal cardiovascular events associated with the predictors were evaluated with multivariable Cox proportional hazard analysis. RESULTS: There were 31 cardiovascular events during the observation period. In a multivariable model adjusted for age, sex, previous cardiovascular disease, P- cystatin C and P- homoarginine, the hazard ratio (HR) associated with an increase in arginine/ADMA ratio by 10 was 0.83 (P=0.03). The HR of a 1 μmol/L increase in P- homoarginine in the same model was 1.78 (P=0.01). A statistically significant interaction between P- homoarginine and P- cystatin C was found in an extended multivariable model. P-SDMA was not associated with increased CVR after adjustment for basic covariates. CONCLUSION: This study demonstrates a negative association between arginine/ADMA ratio and CVR in CKD patients and a positive association between P- homoarginine and CVR. The latter is in contrast to what has been demonstrated by others.
|
Authors | Gunhild Garmo Hov, Knut Ivar Aasarød, Erling Sagen, Arne Åsberg |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 48
Issue 10-11
Pg. 646-51
(Jul 2015)
ISSN: 1873-2933 [Electronic] United States |
PMID | 25828044
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- dimethylarginine
- Homoarginine
- Arginine
|
Topics |
- Adult
- Aged
- Arginine
(analogs & derivatives, blood)
- Biomarkers
(blood)
- Cardiovascular Diseases
(blood, diagnosis, epidemiology)
- Female
- Follow-Up Studies
- Homoarginine
(blood)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Renal Insufficiency, Chronic
(blood, diagnosis, epidemiology)
- Risk Factors
|