[Study of neuroprotective, antihypoxic and antiamnesic effects of new mixture of tripeptides].

Abstract

A new mixture of tripeptides (NMT: H-Lys-Asp-Glu-OH, H-Asp-Glu-Pro-OH, H-Asp-Glu-Arg-OH) in doses of 150 and 300 mg/kg per day produces clearly pronounced neuroprotective effect in rats with brain ischemia and decreases neurologic deficiency 1.1 times more effectively than reference drug semax. NMT (10, 50 and 150 mg/kg) had marked antihypoxic effect on mice in hermetic and altitude chamber. NMT in doses of 10 and 50 mg/kg was more effective than semax in hermetic chamber (1.3 and 1.5 times, respectively) and in a dose of 150 mg/kg in altitude chamber (1.9 times). NMT (50 and 150 mg/kg) had also marked antiamnesic effect on model amnesia caused by scopolamine in rats and was more effective (1.5 and 1.4 times, respectively) than semax in equal doses. NMT (50 and 150 mg/kg) also had marked antiamnesic effect on model amnesia caused by maximal electroshock and complex extreme factors in mice and in both doses was 4 times more effective than semax on the first model and in a dose of 150 mg/kg was 2.9 times more effective on the second model. NMT (50 mg/kg) increased the amplitude of transcallosal evoked potential in rat brain by 69% and was more effective than semax in equal dose. Thus, NMT is a promising neurotropic drug with neuroprotective, antihypoxic and antiamnesic activity.

• Authors: V V Iasnetsov, E A Chertorizhskiĭ, P A Belyĭ, Zh D Bespalova, M V Ovchinnikov, A O Vereshchagina, Iu V Ivanov, Vik V Iasnetsov, S K Kirsanova, V G Motin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 78 Issue 1 Pg. 3-8 ( 2015) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 25826866 (Publication Type: Journal Article)

Chemical References

• Neuroprotective Agents
• Nootropic Agents
• Oligopeptides
• Peptide Fragments
• ACTH (4-7), Pro-Gly-Pro-
• Adrenocorticotropic Hormone
• Scopolamine

Topics

• Adrenocorticotropic Hormone (analogs & derivatives, pharmacology)
• Amnesia (chemically induced, drug therapy, physiopathology)
• Animals
• Brain Ischemia (drug therapy, physiopathology)
• Electroshock
• Evoked Potentials, Motor (drug effects)
• Hypoxia (drug therapy, physiopathology)
• Male
• Mice
• Neuroprotective Agents (chemical synthesis, pharmacology)
• Nootropic Agents (chemical synthesis, pharmacology)
• Oligopeptides (chemical synthesis, pharmacology)
• Peptide Fragments (pharmacology)
• Rats
• Scopolamine