The effect of ferric chloride on superficial bleeding.

Abstract

BACKGROUND:

Controlling superficial bleeding, despite all the progress in surgical science, is still a challenge in some settings.

OBJECTIVES:

This study assesses the hemostatic effects of ferric chloride and compares it with the standard method (suturing technique) to control superficial bleeding.

MATERIALS AND METHODS:

In this animal model study, 60 male Wistar rats were used. An incision, 2 cm long and 0.5 cm deep was made on rat skin and the hemostasis time was recorded using ferric chloride at different concentrations (5%, 10%, 15%, 25%, and 50%) and then using a control (i.e. control of bleeding by suturing). The skin tissue was examined for pathological changes. Finally, the obtained data were entered into SPSS (ver. 16) and analyzed using Kruskal-Wallis test, Mann-Whitney, Kolmogorov-Smirnov, and Wilcoxon signed ranks test.

RESULTS:

The hemostasis time for the ferric chloride concentration group was significantly less than for the control group (P < 0.001).

CONCLUSIONS:

Ferric chloride may be an effective hemostatic agent to control superficial bleeding in rats.

• Authors: Saeed Nouri, Mohammad Reza Sharif, Sare Sahba
• Journal: Trauma monthly (Trauma Mon) Vol. 20 Issue 1 Pg. e18042 (Feb 2015) ISSN: 2251-7464 [Print] Iran
• PMID: 25825694 (Publication Type: Journal Article)