Abstract | BACKGROUND AND OBJECTIVE: MATERIALS AND METHODS: Thirty patients were randomized into two groups: control and laser. LLLT was performed three times a week in the laser group, while control group received sham irradiation. OM severity was assessed according to the World Health Organization (WHO) and National Cancer Institute (NCI) scales. Pro-inflammatory and anti-inflammatory cytokines (TNF-α, IL-6, IL-1β, IL-10, TGF-β), growth factors ( EGF, FGF, VEGF), and metalloproteinases (MMP2/TIMP2, MMP9/TIMP2) concentrations were assessed using ELISA test. Saliva samples were collected on admission, and at the 7th, 21st, and 35th sessions of radiotherapy. RESULTS: The laser group showed a reduction in the severity of OM, which coursed with significantly diminished salivary concentration of EGF and VEGF in the 7th radiotherapy session and of IL-6 and FGF in the 35th. There was a trend for reduced levels of IL-1β, TNF-α, IL-10, TGF-β, MMP2/TIMP2, MMP9/TIMP2 in the laser group compared to the control, however, no statistically significant differences were found. CONCLUSIONS: These findings demonstrated that LLLT was effective in reducing the severity of chemoradiotherapy-induced OM and was associated with the reduction of inflammation and repair.
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Authors | Angélica F Oton-Leite, Geisa Badauy L Silva, Marília O Morais, Tarcília A Silva, Cláudio R Leles, Marize Campos Valadares, Juliana Castro D Pinezi, Aline C Batista, Elismauro F Mendonça |
Journal | Lasers in surgery and medicine
(Lasers Surg Med)
Vol. 47
Issue 4
Pg. 296-305
(Apr 2015)
ISSN: 1096-9101 [Electronic] United States |
PMID | 25824475
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 Wiley Periodicals, Inc. |
Chemical References |
- Cytokines
- Vascular Endothelial Growth Factor A
- Epidermal Growth Factor
- Metalloproteases
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Topics |
- Carcinoma, Squamous Cell
(drug therapy, radiotherapy)
- Chemoradiotherapy
(adverse effects)
- Cytokines
(metabolism)
- Double-Blind Method
- Epidermal Growth Factor
(metabolism)
- Female
- Head and Neck Neoplasms
(drug therapy, radiotherapy)
- Humans
- Low-Level Light Therapy
- Male
- Metalloproteases
(metabolism)
- Middle Aged
- Saliva
(metabolism)
- Severity of Illness Index
- Stomatitis
(radiotherapy)
- Vascular Endothelial Growth Factor A
(metabolism)
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