HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women.

Abstract
Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-α (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-α gene polymorphisms.
AuthorsInes Mrizak, Omar Šerý, Jiří Plesnik, Amel Arfa, Mariem Fekih, Ali Bouslema, Monia Zaouali, Zouhair Tabka, Naim Akhtar Khan
JournalThe British journal of nutrition (Br J Nutr) Vol. 113 Issue 8 Pg. 1330-7 (Apr 28 2015) ISSN: 1475-2662 [Electronic] England
PMID25822988 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CD36 Antigens
  • Dietary Fats
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Oleic Acid
Topics
  • Administration, Oral
  • Adult
  • Alleles
  • CD36 Antigens (genetics)
  • Cluster Analysis
  • Dietary Fats
  • Female
  • Food Preferences
  • Genotype
  • Humans
  • Interleukin-6 (blood)
  • Middle Aged
  • Obesity (physiopathology)
  • Oleic Acid (chemistry)
  • Polymorphism, Single Nucleotide
  • Taste (genetics)
  • Taste Buds (physiology)
  • Taste Perception (genetics)
  • Tumor Necrosis Factor-alpha (genetics)
  • Tunisia

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: