Abstract | BACKGROUND: AIM: The purpose of this study was to determine whether stronger acid suppression more effectively prevents bleeding and high risk ulcer stigma (HRS) after gastric ESD. METHODS: A total of 273 patients who underwent ESD were randomly assigned to one of two treatment groups: the continuous infusion group and the bolus injection group. Second-look endoscopy was performed on the following day after ESD. The incidences and risk factors of HRS identified by second-look endoscopy and delayed bleeding were analyzed. RESULTS: There were no differences in the incidences of HRS and delayed bleeding between two treatment groups. The incidence of HRS was 15.8 % (43/273) and the gross morphology (flat or depressed) was identified as a significant factor associated with HRS. The incidence of delayed bleeding was 8.4 % (23/273) and the gross morphology (flat) and the presence of submucosal invasive cancer were identified as the associated risk factors for delayed bleeding. CONCLUSION: The incidences of delayed bleeding and HRS identified by second-look endoscopy were not affected by PPI infusion methods. Flat or depressed morphologic lesions and submucosal invasive cancer should be closely monitored.
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Authors | Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Joung Boom Hong, Su Bum Park, Su Jin Kim, Mong Cho |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 60
Issue 7
Pg. 2088-96
(Jul 2015)
ISSN: 1573-2568 [Electronic] United States |
PMID | 25821098
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Proton Pump Inhibitors
- Pantoprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
(administration & dosage, therapeutic use)
- Aged
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Endoscopy, Gastrointestinal
(adverse effects)
- Female
- Gastrointestinal Hemorrhage
(prevention & control)
- Humans
- Male
- Middle Aged
- Pantoprazole
- Proton Pump Inhibitors
(administration & dosage, therapeutic use)
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