Abstract | OBJECTIVE: The aim of the present study is to evaluate the efficacy of slow zinc (Zn) release from β- tricalcium phosphate powder (ZnTCP) containing 10 mol% Zn on rats with thermal burns. METHODS: RESULTS: The wound area profiles of all rat groups could be separated into before and after the scab formation at around day 6. The area under the curve (Aw-AUC) for wound area profiles, therefore, was evaluated as an index of therapeutic scores for the thermal wound. The order of Aw-AUC was D3>C>D2>D1. The degree of expansion at the initial stage by thermal burns of group D1 was the lowest and that of group D2 was the highest, and the order was D1<D3<C<D2. CONCLUSIONS:
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Authors | Makoto Otsuka, Haruna Hatakeyama, Masayuki Shikamura, Kuniko Otsuka, Atsuo Ito |
Journal | Bio-medical materials and engineering
(Biomed Mater Eng)
Vol. 25
Issue 2
Pg. 143-56
( 2015)
ISSN: 1878-3619 [Electronic] Netherlands |
PMID | 25813953
(Publication Type: Journal Article)
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Chemical References |
- Calcium Phosphates
- Ointments
- Powders
- beta-tricalcium phosphate
- Zinc Sulfate
- Alkaline Phosphatase
- Zinc
- Zinc Oxide
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Topics |
- Alkaline Phosphatase
(blood)
- Animals
- Burns
(drug therapy)
- Calcium Phosphates
(pharmacology)
- Chemical Phenomena
- Epidermis
(drug effects, pathology)
- Female
- Nanostructures
(chemistry)
- Ointments
(pharmacology)
- Powders
(chemistry)
- Rats
- Regenerative Medicine
- Wound Healing
(drug effects)
- Zinc
(blood, pharmacokinetics)
- Zinc Oxide
(pharmacology)
- Zinc Sulfate
(pharmacology)
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