Detection of anti-streptococcal, antienolase, and anti-neural antibodies in subjects with early-onset psychiatric disorders.

Abstract

INTRODUCTION:

Infection with group A Streptococcus (StrepA) can cause post-infectious sequelae, including a spectrum of childhood-onset obsessive-compulsive (OCD) and tic disorders with autoimmune origin (PANDAS, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections). Until now, no single immunological test has been designed that unequivocally diagnoses these disorders. In this study, we assessed the detection of serum antibodies against human brain enolase (AE), neural tissue (AN) and Streptococcus (AS) as a laboratory tool for the diagnosis of early-onset psychiatric disorders.

METHODOLOGY:

Serum antibodies against human brain enolase, total brain proteins, and total proteins from StrepA were detected by ELISA in 37 patients with a presumptive diagnosis of PANDAS and in 12 healthy subjects from Mexico and Cuba.

RESULTS:

The antibody titers against human brain enolase (AE) and Streptococcal proteins (AS) were higher in patients than in control subjects (t-student, tAE=-2.17, P=0.035; tAS=-2.68, P=0.01, n=12 and 37/group, df=47, significance level 0.05), while the neural antibody titers did not differ between the two groups (P(t)=0.05). The number of subjects (titers> meancontrol + CI95) with simultaneous seropositivity to all three antibodies was higher in the patient group (51.4%) than in the control group (8.3%) group (X2=5.27, P=0.022, df=1, n=49).

CONCLUSIONS:

The simultaneous detection of all three of these antibodies could provide valuable information for the etiologic diagnosis of individuals with early-onset obsessive-compulsive disorders associated with streptococcal infection and, consequently, for prescribing suitable therapy.

• Authors: Humberto Nicolini, Yaumara López, Alma D Genis-Mendoza, Viana Manrique, Lilia Lopez-Canovas, Esperanza Niubo, Lázaro Hernández, María A Bobes, Ana M Riverón, Mavil López-Casamichana, Julio Flores, Nuria Lanzagorta, Camilo De la Fuente-Sandoval, Daniel Santana
• Journal: Actas espanolas de psiquiatria (Actas Esp Psiquiatr) 2015 Mar-Apr Vol. 43 Issue 2 Pg. 35-41 ISSN: 1578-2735 [Electronic] Spain
• PMID: 25812540 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Phosphopyruvate Hydratase

Topics

• Antibodies (blood)
• Child
• Cross-Sectional Studies
• Female
• Humans
• Male
• Mental Disorders (blood, microbiology)
• Nervous System (immunology)
• Obsessive-Compulsive Disorder (blood, microbiology)
• Phosphopyruvate Hydratase (immunology)
• Streptococcal Infections (complications)
• Streptococcus pyogenes (immunology)
• Tic Disorders (blood, microbiology)