[Fertility-sparing treatment for gynecologic cancer].

Abstract

Japanese women bear children at a later age. Thus, fertility-sparing treatment for gynecologic cancer is very important. Per the Japanese treatment guidelines for cervical cancer, the uterus can be preserved by performing cervical conization alone in patients with stage I A1 disease. Radical trachelectomy (RT) is not yet recommended for patients with stage I A2 or I B 1 disease in Japan. Further, RT will not be popular in Japan because cervical cancer can be prevented with HPV vaccine. The efficacy of fertility-sparing treatment with a high-dose of medroxyprogesterone acetate for grade 1 endometrial cancer was proven in a Japan clinical oncology group (JCOG) phase II study. Japanese multi-institutional retrospective investigation data confirm that fertility-sparing surgery is safe for patients with stage I A disease with non-clear cell histology grade 1 or 2. These data suggest that patients with stage I A disease with clear cell histology and those with stage I C disease with non-clear cell histology grade 1 or 2 can be candidates for fertility sparing surgery followed by adjuvant chemotherapy.

• Authors: Hajime Tsunoda
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 3 Pg. 276-82 (Mar 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 25812496 (Publication Type: English Abstract, Journal Article)

Topics

• Age Distribution
• Female
• Fertility
• Genital Neoplasms, Female (pathology, therapy)
• Humans
• Infertility, Female
• Neoplasm Staging