Abstract | BACKGROUND: METHODS: Fifteen CLL/SLL patients with kidney biopsy were identified retrospectively. Demographic, clinical, pathological and laboratory data were assessed at biopsy, and during follow-up. RESULTS: At biopsy 11 patients presented impaired renal function, 7 patients nephrotic syndrome, 6 patients dysproteinemia, and 3 patients cryoglobulinemia. Kidney pathology revealed CLL/SLL-specific monoclonal infiltrate in 10 biopsies, glomerulopathy in 9 biopsies (5 membranoproliferative glomerulonephritis, 2 minimal change disease, 1 glomerulonephritis with organized microtubular monoclonal immunoglobulin deposits, 1 AHL amyloidosis). Five patients presented interstitial granulomas attributed to CLL/SLL. After treatment of the hematological disease, improvement of renal function was observed in 7/11 patients, and remission of nephrotic syndrome in 5/7 patients. During follow-up, aggravation of the kidney disease systematically occurred in the absence of favorable response to hematological treatment. CONCLUSIONS: A broad spectrum of kidney diseases is associated with CLL/SLL. In this setting, kidney biopsy can provide important information for diagnosis and therapeutic guidance.
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Authors | Anne-Laure Poitou-Verkinder, Arnaud Francois, Fanny Drieux, Stéphane Lepretre, Bruno Legallicier, Bruno Moulin, Michel Godin, Dominique Guerrot |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 3
Pg. e0119156
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25811382
(Publication Type: Journal Article, Multicenter Study)
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Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Demography
- Female
- Follow-Up Studies
- Glomerulonephritis
(complications)
- Humans
- Kidney
(diagnostic imaging, metabolism, pathology)
- Leukemia, Lymphocytic, Chronic, B-Cell
(drug therapy, metabolism, pathology)
- Lymphocyte Count
- Male
- Middle Aged
- Nephrotic Syndrome
(complications)
- Radiography
- Recurrence
- Retrospective Studies
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