Abstract |
We examined the effects of late administration of the thromboxane synthetase inhibitor dazmegrel ( UK 38485) and the calcium channel blocker nifedipine in anaesthetised greyhounds subject to occlusion of the left anterior descending coronary artery with reperfusion after 40 min of ischaemia. Administration of dazmegrel, 3 mg/kg i.v., or nifedipine, 5 micrograms/kg + 1 microgram kg-1 min-1 i.v., 25 min after coronary artery occlusion failed to reduce the incidence of reperfusion-induced ventricular fibrillation (controls, 70%; dazmegrel, 50%; nifedipine, 70%; n = 10). Measurement of plasma prostanoid concentrations indicated that within 5 min of receiving dazmegrel there was a significant reduction in thromboxane B2 concentrations in the local coronary vein draining the ischaemic myocardium. The results suggest that the occurrence of reperfusion-induced ventricular fibrillation depends upon the severity of changes occurring during ischaemia. Analysis of various factors suggested that the number of ischaemia-induced arrhythmias, heart rate, and the magnitude of changes in local coronary venous PO2 may be important predictors of reperfusion-induced ventricular fibrillation.
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Authors | S J Coker, J R Parratt |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
1985 Mar-Apr
Vol. 7
Issue 2
Pg. 327-34
ISSN: 0160-2446 [Print] United States |
PMID | 2581088
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Imidazoles
- dazmegrel
- Oxidoreductases
- Thromboxane-A Synthase
- Nifedipine
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Topics |
- Animals
- Blood Gas Analysis
- Coronary Disease
(physiopathology)
- Dogs
- Female
- Hemodynamics
(drug effects)
- Hydrogen-Ion Concentration
- Imidazoles
(administration & dosage, pharmacology, therapeutic use)
- Male
- Nifedipine
(administration & dosage, pharmacology, therapeutic use)
- Oxidoreductases
(antagonists & inhibitors)
- Perfusion
- Thromboxane-A Synthase
(antagonists & inhibitors)
- Ventricular Fibrillation
(etiology, prevention & control)
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