Abstract |
Capillary hemangioma (capillary lobular hemangioma) and cavernous hemangioma (venous malformation) are relatively common oral tumors/malformations and are characterized by increased numbers of normal and abnormal blood vessels. However, the causes of these lesions are not well understood. CD105 ( endoglin) is predominantly expressed in proliferating blood endothelial cells (ECs). We analyzed expressions of CD105, CD34, von Willebrand factor, Ki-67, cyclooxygenase-2 (COX-2), and vascular endothelial growth factor ( VEGF)-A in 31 capillary hemangiomas and 34 cavernous hemangiomas. Staining scores were calculated as the product of the proportion score and intensity score. Morphologically normal oral mucosa specimens (n = 10) were simultaneously evaluated as normal controls. As compared with cavernous hemangiomas and normal controls, capillary hemangiomas had higher staining scores for CD105, VEGF-A, and COX-2. The Ki-67 labeling index was significantly higher in capillary hemangiomas than in cavernous hemangiomas and normal controls (P < 0.01). These findings suggest that the biological characteristics of capillary and cavernous hemangiomas are quite different. The ECs of capillary hemangiomas actively proliferated and were generally regulated by VEGF-A. In contrast, the ECs of cavernous hemangiomas lacked proliferative activity. These results suggest that angiogenesis and vasodilatation of pre-existing blood vessels are important in the development of capillary hemangioma and cavernous hemangioma, respectively.
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Authors | Naoyuki Matsumoto, Motomi Tsuchiya, Shouta Nomoto, Yasuyoshi Matsue, Yohichi Nishikawa, Tsuyoshi Takamura, Hidero Oki, Kazuo Komiyama |
Journal | Journal of oral science
(J Oral Sci)
Vol. 57
Issue 1
Pg. 45-53
(Mar 2015)
ISSN: 1880-4926 [Electronic] Japan |
PMID | 25807908
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD34
- Endoglin
- Ki-67 Antigen
- Vascular Endothelial Growth Factor A
- von Willebrand Factor
- Cyclooxygenase 2
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD34
(metabolism)
- Child
- Cyclooxygenase 2
(metabolism)
- Endoglin
(metabolism)
- Female
- Hemangioma, Capillary
(metabolism)
- Hemangioma, Cavernous
(metabolism)
- Humans
- Immunoenzyme Techniques
- Ki-67 Antigen
(metabolism)
- Male
- Middle Aged
- Mouth Neoplasms
(metabolism)
- Vascular Endothelial Growth Factor A
(metabolism)
- von Willebrand Factor
(metabolism)
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