Capsaicin has many
biological effects, such as
antioxidant, anticancer, and antiangiogenic effects, but it is rarely used because of its high pungency.
Capsiate, a nonpungent
capsaicin analog, also has multiple
biological effects, similar to those of
capsaicin, but does not cause irritation. However, the effect of
capsiate on allergic responses and immune cells has not been well studied. In this study, we investigated the effect of
capsiate on
atopic dermatitis, mouse CD4+ T cells, and mast cell activation.
Capsiate inhibited
DNFB-induced
atopic dermatitis in NC/Nga mice. Topical treatment with
capsiate suppressed serum
IgE levels and
cytokine and
chemokine expression in the skin of
DNFB-treated NC/Nga mice. In addition, it suppressed the activation of CD4+ T cells and mast cells, which are implicated in allergic diseases.
Capsiate inhibited the differentiation of naïve CD4+ T cells into T helper type 1 (Th1), Th2, and Th17 cells. Treatment with
capsiate inhibited the expression of pro-inflammatory
cytokines and degranulation from activated bone marrow-derived mast cells through the inhibition of
extracellular signal-regulated kinase signal pathways. Consistent with these results, treatment with
capsiate inhibited passive cutaneous anaphylaxis. Taken together, our results suggest that
capsiate might be a good candidate molecule for the treatment of allergic diseases such as
atopic dermatitis.