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Photodynamic therapy relieves colitis and prevents colitis-associated carcinogenesis in mice.

AbstractBACKGROUND:
Inflammatory bowel diseases are incurable illnesses of the gastrointestinal tract, which substantially enhance the risk of developing colorectal carcinogenesis. Conventional photodynamic therapy is a clinically approved therapeutic modality used in the treatment of neoplastic diseases. Recent preclinical and clinical studies have shown that photodynamic therapy with low doses of photosensitizer and/or light improves inflammatory conditions, including colitis. This study aims therefore at investigating the therapeutic potential of low-dose photodynamic therapy (LDPDT) with a liposomal formulation of meta-tetra(hydroxyphenyl)chlorin (namely Foslip) in the prevention of colitis-associated cancer in mice.
METHODS:
LDPDT efficacy was evaluated by endoscopic, macroscopic, and histological analysis. Myeloperoxidase levels were quantified by enzyme linked immunosorbent assay and cytokines expression by quantitative RT-PCR analysis. The integrity of the intestinal barrier was evaluated by immunostaining, and bacterial composition of the fecal microbiota was determined by 454 pyrosequencing of V3-V4 region of bacterial 16S rRNA genes.
RESULTS:
LDPDT reduced intestinal tumor growth by decreasing the expression of a wide range of inflammatory mediators and by lowering neutrophil influx. LDPDT treatment prevents onset of a dysbiotic microbiota in the colitis-associated cancer model.
CONCLUSIONS:
LDPDT with Foslip could be considered as a novel treatment modality to prevent colorectal carcinogenesis in patients with inflammatory bowel disease.
AuthorsAurélie Reinhard, Aude Bressenot, Romain Dassonneville, Alexandre Loywick, David Hot, Christophe Audebert, Sophie Marchal, François Guillemin, Mathias Chamaillard, Laurent Peyrin-Biroulet, Lina Bezdetnaya
JournalInflammatory bowel diseases (Inflamm Bowel Dis) Vol. 21 Issue 5 Pg. 985-95 (May 2015) ISSN: 1536-4844 [Electronic] England
PMID25806846 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cytokines
  • Mesoporphyrins
  • Photosensitizing Agents
  • temoporfin
Topics
  • Animals
  • Colitis (chemically induced, complications, pathology)
  • Colonic Neoplasms (etiology, pathology, prevention & control)
  • Colonoscopy
  • Cytokines (metabolism)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gene Expression Profiling
  • Humans
  • Immunoenzyme Techniques
  • Lymphoma, Large B-Cell, Diffuse (drug therapy, metabolism, pathology)
  • Mesoporphyrins (therapeutic use)
  • Mice
  • Mice, Inbred C57BL
  • Photochemotherapy
  • Photosensitizing Agents (therapeutic use)

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