Abstract |
β- Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β- sitosterol is effective against enlarged prostate in human clinical trials and has anti- cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β- sitosterol that may underlie its beneficial effects.
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Authors | Brett Lomenick, Heping Shi, Jing Huang, Chuo Chen |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 25
Issue 21
Pg. 4976-4979
(Nov 01 2015)
ISSN: 1464-3405 [Electronic] England |
PMID | 25804720
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Lipopolysaccharides
- Sitosterols
- Synaptotagmin I
- gamma-sitosterol
- Peroxisomal Multifunctional Protein-2
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Topics |
- Animals
- Binding Sites
- Humans
- Lipopolysaccharides
(pharmacology)
- Macrophages
(cytology, drug effects)
- Mice
- Molecular Conformation
- Peroxisomal Multifunctional Protein-2
(chemistry, metabolism)
- Protein Binding
- Sitosterols
(chemistry, metabolism, pharmacology)
- Synaptotagmin I
(chemistry, metabolism)
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