[Initial results of hyperthermia in palliative therapy of cancers in the ENT area].

Abstract

Preliminary results of an interdisciplinary study, conducted to investigate the efficacy of combined local hyperthermia and radiation/chemotherapy on carcinoma of head and neck, are reported. Upto now, eleven patients with recurrent squamous cell carcinoma of head and neck were treated, all of them had loco-regional recurrence, and 2 distant metastases in addition. 7 patients were pretreated by surgery and radiotherapy, 4 by radiotherapy only, and 6 by chemotherapy. Microwave-induced low-dose local hyperthermia was combined with radiotherapy (telecobalt 1100-2400 rad) 6 cases (group A) and with chemotherapy (bleomycin and cis-platin/bleomycin) in 5 patients (group B). Intratumoural temperatures between 43 and 45 degrees C were achieved for at least 30 minutes. The loco-regional efficacy of hyperthermia was assessed. 10/11 patients with 13 tumours could be evaluated, Group A: 3 CR, 4 PR, Group B: 1 PR, 4 MR and 1 NC.

• Authors: R Jakse, P Steindorfer, R Germann, J Kraft-Kinz, A Hackl, G Schneider, A Scherlacher
• Journal: Laryngologie, Rhinologie, Otologie (Laryngol Rhinol Otol (Stuttg)) Vol. 64 Issue 2 Pg. 52-7 (Feb 1985) ISSN: 0340-1588 [Print] Germany
• Vernacular Title: Erste Ergebnisse der Hyperthermie in der Palliativtherapie von Karzinomen im HNO-Bereich.
• PMID: 2580203 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cobalt Radioisotopes
• Cisplatin

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (therapy)
• Cisplatin (therapeutic use)
• Cobalt Radioisotopes (therapeutic use)
• Combined Modality Therapy
• Humans
• Hyperthermia, Induced
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Recurrence, Local (therapy)
• Otorhinolaryngologic Neoplasms (therapy)
• Palliative Care
• Radioisotope Teletherapy
• Radiotherapy Dosage