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Structure-activity relationships of benzhydrol derivatives based on 1'-acetoxychavicol acetate (ACA) and their inhibitory activities on multiple myeloma cell growth via inactivation of the NF-κB pathway.

Abstract
1'-Acetoxychavicol acetate (ACA), which was isolated from the rhizomes of Zingiberaceae, exhibits various biological actions, including anti-inflammatory, anti-human immunodeficiency virus (HIV), and anti-cancer activities. ACA represents an attractive candidate for the treatment of many cancers. We herein examined the structure-activity relationships of ACA derivatives based on the benzhydrol skeleton in human leukemia cells (HL-60). Our results revealed that the ACA derivatives synthesized (ACA, 1, and 18) had inhibitory effects on the growth of multiple myeloma cells (IM-9 cells) by inactivating the NF-κB pathway.
AuthorsTakashi Misawa, Kosuke Dodo, Minoru Ishikawa, Yuichi Hashimoto, Morihiko Sagawa, Masahiro Kizaki, Hiroshi Aoyama
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 23 Issue 9 Pg. 2241-6 (May 01 2015) ISSN: 1464-3391 [Electronic] England
PMID25801158 (Publication Type: Journal Article)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Benzhydryl Compounds
  • Benzyl Alcohols
  • NF-kappa B
  • benzohydrol
  • 1'-acetoxychavicol acetate
Topics
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Benzhydryl Compounds (chemical synthesis, chemistry, pharmacology)
  • Benzyl Alcohols (chemistry)
  • Cell Proliferation (drug effects)
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Molecular Structure
  • Multiple Myeloma (drug therapy, pathology)
  • NF-kappa B (antagonists & inhibitors, metabolism)
  • Structure-Activity Relationship

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