Abstract |
1'-Acetoxychavicol acetate (ACA), which was isolated from the rhizomes of Zingiberaceae, exhibits various biological actions, including anti-inflammatory, anti-human immunodeficiency virus (HIV), and anti- cancer activities. ACA represents an attractive candidate for the treatment of many cancers. We herein examined the structure-activity relationships of ACA derivatives based on the benzhydrol skeleton in human leukemia cells (HL-60). Our results revealed that the ACA derivatives synthesized (ACA, 1, and 18) had inhibitory effects on the growth of multiple myeloma cells (IM-9 cells) by inactivating the NF-κB pathway.
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Authors | Takashi Misawa, Kosuke Dodo, Minoru Ishikawa, Yuichi Hashimoto, Morihiko Sagawa, Masahiro Kizaki, Hiroshi Aoyama |
Journal | Bioorganic & medicinal chemistry
(Bioorg Med Chem)
Vol. 23
Issue 9
Pg. 2241-6
(May 01 2015)
ISSN: 1464-3391 [Electronic] England |
PMID | 25801158
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Benzhydryl Compounds
- Benzyl Alcohols
- NF-kappa B
- benzohydrol
- 1'-acetoxychavicol acetate
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Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Benzhydryl Compounds
(chemical synthesis, chemistry, pharmacology)
- Benzyl Alcohols
(chemistry)
- Cell Proliferation
(drug effects)
- Cells, Cultured
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- HL-60 Cells
- Humans
- Molecular Structure
- Multiple Myeloma
(drug therapy, pathology)
- NF-kappa B
(antagonists & inhibitors, metabolism)
- Structure-Activity Relationship
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