Abstract | OBJECTIVES: METHODS: Medical records of the patients were reviewed. All six patients met the Bohan and Peter diagnostic criteria for JDM. RESULTS: A resolution of calcinosis was observed in four of the six patients with JDM following the use of bisphosphonates and intensive immunosuppressive therapy with or without IVIG. Bisphosphonates were unable to either decelerate the progression of calcinosis or improve calcinosis in cases 5 and 6. In case 5, it took a relatively long time to control the disease activity despite the appropriate immunsuppressive treatment and she experienced multiple flares of active JDM. Case 6 had a long duration of severe active disease before treatment initiation. No important adverse event was observed. CONCLUSIONS:
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Authors | Asli Celebi Tayfur, Rezan Topaloglu, Bora Gulhan, Yelda Bilginer |
Journal | Modern rheumatology
(Mod Rheumatol)
Vol. 25
Issue 4
Pg. 615-20
(Jul 2015)
ISSN: 1439-7609 [Electronic] England |
PMID | 25800510
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
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Topics |
- Bone Density Conservation Agents
(therapeutic use)
- Calcinosis
(diagnosis, drug therapy, metabolism)
- Child
- Child, Preschool
- Dermatomyositis
(complications, diagnosis, drug therapy)
- Diphosphonates
(therapeutic use)
- Disease Progression
- Female
- Humans
- Infant
- Retrospective Studies
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